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Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature response circuit of Caenorhabditis elegans.
Ohta, Akane; Kuhara, Atsushi.
Affiliation
  • Ohta A; Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Konan University, Kobe 658-8501, Japan.
Neurosci Res ; 76(3): 119-24, 2013 Jul.
Article in En | MEDLINE | ID: mdl-23542220
ABSTRACT
How the nervous system controls the sensation and memory of information from the environment is an essential question. The nematode Caenorhabditis elegans is a useful model for elucidating neural information processing that mediates sensation and memory. The entire nervous system of C. elegans consists of only 302 neurons, and their wiring diagram has been revealed by electron microscopy analysis. Here, we review the molecular and physiological mechanisms responsible for the neural circuit-mediated temperature-seeking behavior (thermotaxis) in C. elegans. Recent molecular biology studies and optogenetic analyses, such as the optical manipulation of neural activity, and neural imaging have revealed the novel concept of neural calculation. Most significantly, trimetric G proteincoupled thermosensation, single sensory neuron-based memory, and the orchestrated synaptic transmission system have been elucidated.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thermosensing / Caenorhabditis elegans / GTP-Binding Proteins / Caenorhabditis elegans Proteins / Neural Pathways Limits: Animals Language: En Journal: Neurosci Res Year: 2013 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thermosensing / Caenorhabditis elegans / GTP-Binding Proteins / Caenorhabditis elegans Proteins / Neural Pathways Limits: Animals Language: En Journal: Neurosci Res Year: 2013 Document type: Article