[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
Eksp Klin Farmakol
; 76(2): 9-12, 2013.
Article
in Ru
| MEDLINE
| ID: mdl-23631276
ABSTRACT
Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. This is accompanied by signs of stabilization of cardiomyocyte membranes and reduction in the degree of tissue hypoxia. The efficiency of trimetazidine decreases with increasing age in 24-month-aged rats, the direction of changes is retained, but they are less pronounced.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trimetazidine
/
Vasodilator Agents
/
Myocardial Ischemia
/
Myocytes, Cardiac
/
Glycolysis
/
Myocardium
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Ru
Journal:
Eksp Klin Farmakol
Year:
2013
Document type:
Article