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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Inoue, Satoshi; Hao, Zhenyue; Elia, Andrew J; Cescon, David; Zhou, Lily; Silvester, Jennifer; Snow, Bryan; Harris, Isaac S; Sasaki, Masato; Li, Wanda Y; Itsumi, Momoe; Yamamoto, Kazuo; Ueda, Takeshi; Dominguez-Brauer, Carmen; Gorrini, Chiara; Chio, Iok In Christine; Haight, Jillian; You-Ten, Annick; McCracken, Susan; Wakeham, Andrew; Ghazarian, Danny; Penn, Linda J Z; Melino, Gerry; Mak, Tak W.
Affiliation
  • Inoue S; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada.
Genes Dev ; 27(10): 1101-14, 2013 May 15.
Article in En | MEDLINE | ID: mdl-23699408
Subject(s)
Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p15/metabolism; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Down-Regulation; Nuclear Proteins/antagonists & inhibitors; Oncogene Protein p21(ras)/metabolism; Protein Inhibitors of Activated STAT/antagonists & inhibitors; Proto-Oncogene Proteins c-myc/antagonists & inhibitors; Ubiquitin-Protein Ligases/metabolism; 9,10-Dimethyl-1,2-benzanthracene/pharmacology; Animals; Cell Transformation, Neoplastic/genetics; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p15/biosynthesis; Cyclin-Dependent Kinase Inhibitor p15/genetics; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis; Cyclin-Dependent Kinase Inhibitor p21/genetics; Female; Genes, ras; Keratinocytes/drug effects; Keratinocytes/metabolism; Keratinocytes/pathology; Male; Mice; Mice, Knockout; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Oncogene Protein p21(ras)/antagonists & inhibitors; Oncogene Protein p21(ras)/genetics; Protein Inhibitors of Activated STAT/deficiency; Protein Inhibitors of Activated STAT/genetics; Protein Inhibitors of Activated STAT/metabolism; Proto-Oncogene Proteins c-myc/deficiency; Proto-Oncogene Proteins c-myc/genetics; Proto-Oncogene Proteins c-myc/metabolism; Signal Transduction; Skin Neoplasms/chemically induced; Skin Neoplasms/genetics; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Tetradecanoylphorbol Acetate/pharmacology; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases/deficiency; Ubiquitin-Protein Ligases/genetics
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Down-Regulation / Oncogene Protein p21(ras) / Cell Transformation, Neoplastic / Proto-Oncogene Proteins c-myc / Ubiquitin-Protein Ligases / Protein Inhibitors of Activated STAT / Cyclin-Dependent Kinase Inhibitor p15 / Cyclin-Dependent Kinase Inhibitor p21 Language: En Journal: Genes Dev Year: 2013 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Down-Regulation / Oncogene Protein p21(ras) / Cell Transformation, Neoplastic / Proto-Oncogene Proteins c-myc / Ubiquitin-Protein Ligases / Protein Inhibitors of Activated STAT / Cyclin-Dependent Kinase Inhibitor p15 / Cyclin-Dependent Kinase Inhibitor p21 Language: En Journal: Genes Dev Year: 2013 Document type: Article