Pretreatment of donor islets with the Na(+) /Ca(2+) exchanger inhibitor improves the efficiency of islet transplantation.

Mera, T; Itoh, T; Kita, S; Kodama, S; Kojima, D; Nishinakamura, H; Okamoto, K; Ohkura, M; Nakai, J; Iyoda, T; Iwamoto, T; Matsuda, T; Baba, A; Omori, K; Ono, J; Watarai, H; Taniguchi, M; Yasunami, Y

Mera, T; Itoh, T; Kita, S; Kodama, S; Kojima, D; Nishinakamura, H; Okamoto, K; Ohkura, M; Nakai, J; Iyoda, T; Iwamoto, T; Matsuda, T; Baba, A; Omori, K; Ono, J; Watarai, H; Taniguchi, M; Yasunami, Y.

Affiliation

Mera T; Central Research Institute for Islet Biology, Fukuoka University, Fukuoka, Japan.

Am J Transplant ; 13(8): 2154-60, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23746308

Subject(s)

Aniline Compounds/pharmacology; Diabetes Mellitus, Experimental/prevention & control; Diabetes Mellitus, Type 1/immunology; Graft Rejection/immunology; Islets of Langerhans Transplantation/immunology; Islets of Langerhans/immunology; Phenyl Ethers/pharmacology; Sodium-Calcium Exchanger/antagonists & inhibitors; Animals; Diabetes Mellitus, Experimental/enzymology; Diabetes Mellitus, Experimental/immunology; Flow Cytometry; Graft Rejection/drug therapy; Graft Rejection/metabolism; HMGB1 Protein/metabolism; Humans; Hypoxia/metabolism; Hypoxia/pathology; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Sodium-Calcium Exchanger/metabolism

Key words

Early loss of transplanted islets; Na+/Ca2+ exchanger; hypoxia; islet transplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Islets of Langerhans Transplantation / Islets of Langerhans / Sodium-Calcium Exchanger / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 / Graft Rejection / Aniline Compounds Limits: Animals / Humans / Male Language: En Journal: Am J Transplant Year: 2013 Document type: Article

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