Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma.

Zhang, B; Dong, L-W; Tan, Y-X; Zhang, J; Pan, Y-F; Yang, C; Li, M-H; Ding, Z-W; Liu, L-J; Jiang, T-Y; Yang, J-H; Wang, H-Y

Zhang, B; Dong, L-W; Tan, Y-X; Zhang, J; Pan, Y-F; Yang, C; Li, M-H; Ding, Z-W; Liu, L-J; Jiang, T-Y; Yang, J-H; Wang, H-Y.

Affiliation

Zhang B; International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, 225 Changhai Road, Shanghai 200438, People's Republic of China.

Br J Cancer ; 109(1): 14-23, 2013 Jul 09.

Article in En | MEDLINE | ID: mdl-23764751

Subject(s)

Aspartate-Ammonia Ligase/metabolism; Carcinoma, Hepatocellular; Liver Neoplasms; Adult; Animals; Asparaginase/pharmacology; Aspartate-Ammonia Ligase/genetics; Biomarkers, Tumor/metabolism; Carcinoma, Hepatocellular/enzymology; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/surgery; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Liver Neoplasms/enzymology; Liver Neoplasms/mortality; Liver Neoplasms/surgery; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Staging; Prognosis; RNA Interference; RNA, Small Interfering; Survival; Tissue Array Analysis; Xenograft Model Antitumor Assays; alpha-Fetoproteins/analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspartate-Ammonia Ligase / Carcinoma, Hepatocellular / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Br J Cancer Year: 2013 Document type: Article

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