Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C.

Sumida, K; Shimoda, S; Iwasaka, S; Hisamoto, S; Kawanaka, H; Akahoshi, T; Ikegami, T; Shirabe, K; Shimono, N; Maehara, Y; Selmi, C; Gershwin, M E; Akashi, K

Sumida, K; Shimoda, S; Iwasaka, S; Hisamoto, S; Kawanaka, H; Akahoshi, T; Ikegami, T; Shirabe, K; Shimono, N; Maehara, Y; Selmi, C; Gershwin, M E; Akashi, K.

Affiliation

Sumida K; Department of Medicine and Biosystemic Science, Kyushu University, Fukuoka, Japan.

Clin Exp Immunol ; 174(1): 172-8, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23773130

Subject(s)

CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/pathology; Hepatitis C, Chronic/immunology; Hepatitis C, Chronic/pathology; Aged; Antigen-Presenting Cells/immunology; Antigen-Presenting Cells/pathology; Antigen-Presenting Cells/virology; Biomarkers/blood; Biomarkers/metabolism; CD8-Positive T-Lymphocytes/virology; Female; Hepatitis A Virus Cellular Receptor 2; Hepatitis C, Chronic/blood; Humans; Liver Cirrhosis/blood; Liver Cirrhosis/immunology; Liver Cirrhosis/pathology; Male; Membrane Proteins/biosynthesis; Membrane Proteins/blood; Middle Aged; Programmed Cell Death 1 Receptor/biosynthesis; Programmed Cell Death 1 Receptor/blood; Spleen/immunology; Spleen/pathology; Spleen/virology; Splenectomy; Thrombocytopenia/complications; Thrombocytopenia/immunology; Thrombocytopenia/pathology

Key words

PD-1; Tim-3; hepatitis C; liver cirrhosis; portal hypertension; splenectomy

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 4_TD / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Hepatitis C, Chronic Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Exp Immunol Year: 2013 Document type: Article

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