Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort.
Nutr Metab Cardiovasc Dis
; 23(12): 1239-46, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-23786824
ABSTRACT
BACKGROUND AND AIMS:
Whether lipoprotein (a) [Lp(a)] concentration is associated with metabolic syndrome (MetS) and pre-clinical atherosclerosis in different ethnic groups is uncertain. The association between Lp(a), MetS and a measure of pre-clinical atherosclerosis was studied in a large Asian cohort. METHODS ANDRESULTS:
Data were analyzed from a South Korean occupational cohort who underwent a cardiac computed tomography (CT) estimation of CAC score and measurements of cardiovascular risk factors (n = 14,583 people). The key exposure was an Lp(a) concentration in the top quartile (>38.64 mg/dL)) with a CAC score >0 as the outcome variable and measure of pre-clinical atherosclerosis. Logistic regression was used to describe the associations. 1462 participants had a CAC score >0. In the lowest Lp(a) quartile (<11.29 mg/dL), 25.8% had MetS, compared with 16.1% in the highest Lp(a) quartile (>38.64 mg/dL (p < 0.001). MetS, and component features, were inversely related to Lp(a) concentration (all p < 0.0001). In the highest Lp(a) quartile group, there was an association between Lp(a) and CAC score >0 in men (OR 1.21[1.05, 1.40], p = 0.008), and women (OR 1.62[1.03, 2.55], p = 0.038), after adjustment for age, sex, lipid lowering therapy, and multiple cardiovascular risk factors. There was no evidence of an interaction between highest quartile Lp(a) and either high LDLc (>147 mg/dL) (p = 0.99), or MetS (p = 0.84) on the association with CAC score >0.CONCLUSION:
Lp(a) levels are inversely related to MetS and its components. There was a robust association between Lp(a) concentration >38.6 mg/dL and marker of early atherosclerosis in both men and women, regardless of LDLc, level MetS or other cardiovascular risk factors.Key words
Atherosclerosis; BMI; CAC; CVD; Cardio-metabolic risk factors; Cardiovascular disease (CVD); Coronary artery calcium (CAC) score; DBP; FRS; Framingham Risk Score; HDLc; Lp(a); MetS; Metabolic syndrome (MetS); SBP; TG; body mass index; cardiovascular disease; coronary artery calcium score; diastolic blood pressure; high density lipoprotein cholesterol; metabolic syndrome; systolic blood pressure; triglyceride
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Calcium
/
Lipoprotein(a)
/
Metabolic Syndrome
/
Atherosclerosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Nutr Metab Cardiovasc Dis
Year:
2013
Document type:
Article