Inter-residue coupling contributes to high-affinity subtype-selective binding of &#945;-bungarotoxin to nicotinic receptors.

Sine, Steven M; Huang, Sun; Li, Shu-Xing; daCosta, Corrie J B; Chen, Lin

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.

Sine, Steven M; Huang, Sun; Li, Shu-Xing; daCosta, Corrie J B; Chen, Lin.

Affiliation

Sine SM; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55902, USA. sine@mayo.edu

Biochem J ; 454(2): 311-21, 2013 Sep 01.

Article in En | MEDLINE | ID: mdl-23802200

Subject(s)

Bungarotoxins/metabolism; Models, Molecular; Neurotoxins/metabolism; Receptors, Nicotinic/metabolism; Receptors, Serotonin, 5-HT3/metabolism; Reptilian Proteins/metabolism; Tyrosine/chemistry; Amino Acid Substitution; Animals; Binding Sites; Bungarotoxins/chemistry; Bungarus; HEK293 Cells; Humans; Ligands; Mutant Proteins/chemistry; Mutant Proteins/metabolism; Neurotoxins/chemistry; Peptide Fragments/chemistry; Peptide Fragments/genetics; Peptide Fragments/metabolism; Protein Conformation; Protein Interaction Domains and Motifs; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Receptors, Nicotinic/chemistry; Receptors, Nicotinic/genetics; Receptors, Serotonin, 5-HT3/chemistry; Receptors, Serotonin, 5-HT3/genetics; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Reptilian Proteins/chemistry; alpha7 Nicotinic Acetylcholine Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Bungarotoxins / Models, Molecular / Receptors, Nicotinic / Reptilian Proteins / Receptors, Serotonin, 5-HT3 / Neurotoxins Limits: Animals / Humans Language: En Journal: Biochem J Year: 2013 Document type: Article

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