Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors.

Wissing, Michel D; Mendonca, Janet; Kortenhorst, Madeleine S Q; Kaelber, Nadine S; Gonzalez, Matthew; Kim, Eunice; Hammers, Hans; van Diest, Paul J; Carducci, Michael A; Kachhap, Sushant K

Wissing, Michel D; Mendonca, Janet; Kortenhorst, Madeleine S Q; Kaelber, Nadine S; Gonzalez, Matthew; Kim, Eunice; Hammers, Hans; van Diest, Paul J; Carducci, Michael A; Kachhap, Sushant K.

Affiliation

Wissing MD; 2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions; 1650 Orleans St., CRB-I 1M53, Baltimore, MD 21231, USA. kachhsu@jhmi.edu.

FASEB J ; 27(10): 4279-93, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23884428

Subject(s)

Cell Cycle Proteins/antagonists & inhibitors; Histone Deacetylase Inhibitors/pharmacology; Prostatic Neoplasms/enzymology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Pteridines/pharmacology; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Drug Therapy, Combination; Humans; Hydroxamic Acids/pharmacology; Male; Valproic Acid/pharmacology; Vorinostat; Polo-Like Kinase 1

Key words

HDAC; Plk1; mitotic kinases; spindle assembly checkpoint; synergy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Pteridines / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Histone Deacetylase Inhibitors Limits: Humans / Male Language: En Journal: FASEB J Year: 2013 Document type: Article

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