The P2X7 receptor-inflammasome complex has a role in modulating the inflammatory response in primary Sjögren's syndrome.

Baldini, C; Rossi, C; Ferro, F; Santini, E; Seccia, V; Donati, V; Solini, A

Baldini, C; Rossi, C; Ferro, F; Santini, E; Seccia, V; Donati, V; Solini, A.

Affiliation

Baldini C; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

J Intern Med ; 274(5): 480-9, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23906036

Subject(s)

Inflammasomes/physiology; Inflammation/physiopathology; Receptors, Purinergic P2X7/physiology; Sjogren's Syndrome/physiopathology; Blotting, Western; Carrier Proteins/analysis; Carrier Proteins/physiology; Case-Control Studies; Female; Humans; Interleukin-18/analysis; Interleukin-18/physiology; Interleukin-1beta/analysis; Interleukin-1beta/physiology; Middle Aged; Monocytes/chemistry; Monocytes/physiology; NLR Family, Pyrin Domain-Containing 3 Protein; Real-Time Polymerase Chain Reaction; Receptors, Purinergic P2X7/analysis; Salivary Glands/chemistry; Salvia/chemistry; Sjogren's Syndrome/immunology

Key words

P2X7 receptor; Sjögren's syndrome; inflammasome; interleukin-18

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sjogren's Syndrome / Inflammasomes / Receptors, Purinergic P2X7 / Inflammation Type of study: Observational_studies Limits: Female / Humans / Middle aged Language: En Journal: J Intern Med Year: 2013 Document type: Article

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