Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Putoczki, Tracy L; Thiem, Stefan; Loving, Andrea; Busuttil, Rita A; Wilson, Nicholas J; Ziegler, Paul K; Nguyen, Paul M; Preaudet, Adele; Farid, Ryan; Edwards, Kirsten M; Boglev, Yeliz; Luwor, Rodney B; Jarnicki, Andrew; Horst, David; Boussioutas, Alex; Heath, Joan K; Sieber, Oliver M; Pleines, Irina; Kile, Benjamin T; Nash, Andrew; Greten, Florian R; McKenzie, Brent S; Ernst, Matthias

Putoczki, Tracy L; Thiem, Stefan; Loving, Andrea; Busuttil, Rita A; Wilson, Nicholas J; Ziegler, Paul K; Nguyen, Paul M; Preaudet, Adele; Farid, Ryan; Edwards, Kirsten M; Boglev, Yeliz; Luwor, Rodney B; Jarnicki, Andrew; Horst, David; Boussioutas, Alex; Heath, Joan K; Sieber, Oliver M; Pleines, Irina; Kile, Benjamin T; Nash, Andrew; Greten, Florian R; McKenzie, Brent S; Ernst, Matthias.

Affiliation

Putoczki TL; Ludwig Institute for Cancer Research, Melbourne, VIC 3050, Australia. tracy.putoczki@wehi.edu.au

Cancer Cell ; 24(2): 257-71, 2013 Aug 12.

Article in En | MEDLINE | ID: mdl-23948300

Subject(s)

Cell Transformation, Neoplastic/immunology; Gastrointestinal Neoplasms/immunology; Interleukin-11/metabolism; Interleukin-6/metabolism; Animals; Gastric Mucosa/immunology; Gastric Mucosa/metabolism; Gastrointestinal Neoplasms/genetics; Gastrointestinal Neoplasms/therapy; Humans; Interleukin-11/genetics; Interleukin-11/immunology; Interleukin-6/genetics; Interleukin-6/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Molecular Targeted Therapy; Xenograft Model Antitumor Assays

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Interleukin-6 / Interleukin-11 / Gastrointestinal Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Cell Year: 2013 Document type: Article

Fulltext

XML

PubMed Links

Search on Google