c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma.

Wang, Lei; Zhang, Xiang; Jia, Lin-Tao; Hu, Si-Jun; Zhao, Jing; Yang, Jian-Dong; Wen, Wei-Hong; Wang, Zhe; Wang, Tao; Zhao, Jun; Wang, Rui-An; Meng, Yan-Ling; Nie, Yong-Zhan; Dou, Ke-Feng; Chen, Si-Yi; Yao, Li-Bo; Fan, Dai-Ming; Zhang, Rui; Yang, An-Gang

Wang, Lei; Zhang, Xiang; Jia, Lin-Tao; Hu, Si-Jun; Zhao, Jing; Yang, Jian-Dong; Wen, Wei-Hong; Wang, Zhe; Wang, Tao; Zhao, Jun; Wang, Rui-An; Meng, Yan-Ling; Nie, Yong-Zhan; Dou, Ke-Feng; Chen, Si-Yi; Yao, Li-Bo; Fan, Dai-Ming; Zhang, Rui; Yang, An-Gang.

Affiliation

Wang L; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China; Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.

Hepatology ; 59(5): 1850-63, 2014 May.

Article in En | MEDLINE | ID: mdl-24002871

Subject(s)

Carcinoma, Hepatocellular/genetics; Gene Expression Regulation, Neoplastic; Gene Silencing; Liver Neoplasms/genetics; MicroRNAs/physiology; Proto-Oncogene Proteins c-myc/physiology; Animals; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/pathology; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Humans; Liver Neoplasms/mortality; Liver Neoplasms/pathology; Mice; Mice, Inbred BALB C; MicroRNAs/antagonists & inhibitors; Polycomb Repressive Complex 2/metabolism; Polycomb Repressive Complex 2/physiology; Receptors, CXCR/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-myc / Carcinoma, Hepatocellular / Gene Silencing / MicroRNAs / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hepatology Year: 2014 Document type: Article

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