Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.

Zhang, Kai-Liang; Han, Lei; Chen, Lu-Yue; Shi, Zhen-Dong; Yang, Ming; Ren, Yu; Chen, Ling-Chao; Zhang, Jun-Xia; Pu, Pei-Yu; Kang, Chun-Sheng

Zhang, Kai-Liang; Han, Lei; Chen, Lu-Yue; Shi, Zhen-Dong; Yang, Ming; Ren, Yu; Chen, Ling-Chao; Zhang, Jun-Xia; Pu, Pei-Yu; Kang, Chun-Sheng.

Affiliation

Zhang KL; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China; Chinese Glioma Cooperative Group (CGCG), China.

Cancer Lett ; 342(1): 139-49, 2014 Jan 01.

Article in En | MEDLINE | ID: mdl-24012640

Subject(s)

Brain Neoplasms/metabolism; ErbB Receptors/metabolism; Glioblastoma/metabolism; MicroRNAs/genetics; 3' Untranslated Regions; Animals; Antibodies, Monoclonal, Humanized/pharmacology; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Base Sequence; Binding Sites; Brain Neoplasms/drug therapy; Brain Neoplasms/pathology; Cell Line, Tumor; ErbB Receptors/antagonists & inhibitors; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Glioblastoma/drug therapy; Glioblastoma/pathology; Humans; Mice; Mice, Nude; Neoplasm Invasiveness; PPAR alpha/genetics; PPAR alpha/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA Interference; Transcription Factor AP-1/metabolism; Tumor Burden; Von Hippel-Lindau Tumor Suppressor Protein/metabolism; Wnt Signaling Pathway; Xenograft Model Antitumor Assays; beta Catenin/metabolism

Key words

EGFR; Feedback loop; Glioblastoma; miR-21

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / MicroRNAs / ErbB Receptors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Lett Year: 2014 Document type: Article

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