Unexpected toxicity of cetuximab combined with conventional chemoradiotherapy in patients with locally advanced anal cancer: results of the UNICANCER ACCORD 16 phase II trial.

Deutsch, E; Lemanski, C; Pignon, J P; Levy, A; Delarochefordiere, A; Martel-Lafay, I; Rio, E; Malka, D; Conroy, T; Miglianico, L; Becouarn, Y; Malekzadeh, K; Paris, E; Juzyna, B; Ezra, P; Azria, D

Deutsch, E; Lemanski, C; Pignon, J P; Levy, A; Delarochefordiere, A; Martel-Lafay, I; Rio, E; Malka, D; Conroy, T; Miglianico, L; Becouarn, Y; Malekzadeh, K; Paris, E; Juzyna, B; Ezra, P; Azria, D.

Affiliation

Deutsch E; Department of Radiotherapy, Institut Gustave-Roussy, Villejuif.

Ann Oncol ; 24(11): 2834-8, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24026540

Subject(s)

Anus Neoplasms/drug therapy; Anus Neoplasms/radiotherapy; Drug-Related Side Effects and Adverse Reactions/pathology; Neoplasm Recurrence, Local/drug therapy; Adult; Aged; Antibodies, Monoclonal, Humanized/administration & dosage; Anus Neoplasms/pathology; Cetuximab; Chemoradiotherapy/adverse effects; Cisplatin/administration & dosage; Disease-Free Survival; Drug-Related Side Effects and Adverse Reactions/classification; Female; Fluorouracil/administration & dosage; Humans; Male; Middle Aged; Neoplasm Recurrence, Local/pathology; Neoplasm Recurrence, Local/radiotherapy; Radiotherapy/adverse effects

Key words

anal cancer; cetuximab; chemoradiotherapy; phase II; targeted therapy; toxicity

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Anus Neoplasms / Drug-Related Side Effects and Adverse Reactions / Neoplasm Recurrence, Local Type of study: Clinical_trials / Guideline Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Oncol Year: 2013 Document type: Article

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