Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.

Zheng, Ying; McFarland, Braden C; Drygin, Denis; Yu, Hao; Bellis, Susan L; Kim, Hyunsoo; Bredel, Markus; Benveniste, Etty N

Zheng, Ying; McFarland, Braden C; Drygin, Denis; Yu, Hao; Bellis, Susan L; Kim, Hyunsoo; Bredel, Markus; Benveniste, Etty N.

Affiliation

Zheng Y; Authors' Affiliations: Departments of Cell, Developmental and Integrative Biology, Pathology, and Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama; and Cylene Pharmaceuticals, San Diego, California.

Clin Cancer Res ; 19(23): 6484-94, 2013 Dec 01.

Article in En | MEDLINE | ID: mdl-24036851

Subject(s)

Antineoplastic Agents/pharmacology; Brain Neoplasms/enzymology; Glioblastoma/enzymology; Naphthyridines/pharmacology; Signal Transduction; Animals; Antineoplastic Agents/therapeutic use; Brain Neoplasms/drug therapy; Brain Neoplasms/genetics; Brain Neoplasms/pathology; Casein Kinase II/genetics; Casein Kinase II/metabolism; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Enzyme Activation; Female; Gene Amplification; Gene Dosage; Glioblastoma/drug therapy; Glioblastoma/genetics; Glioblastoma/pathology; Humans; Mice; Mice, Nude; Naphthyridines/therapeutic use; Phenazines; Proto-Oncogene Proteins c-akt/metabolism; STAT3 Transcription Factor/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Signal Transduction / Glioblastoma / Naphthyridines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Year: 2013 Document type: Article

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