Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.

Cherny, Izhack; Greisen, Per; Ashani, Yacov; Khare, Sagar D; Oberdorfer, Gustav; Leader, Haim; Baker, David; Tawfik, Dan S

Cherny, Izhack; Greisen, Per; Ashani, Yacov; Khare, Sagar D; Oberdorfer, Gustav; Leader, Haim; Baker, David; Tawfik, Dan S.

Affiliation

Cherny I; Department of Biological Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.

ACS Chem Biol ; 8(11): 2394-403, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-24041203

Subject(s)

Chemical Warfare Agents; Cholinesterase Inhibitors/chemistry; Computer Simulation; Organothiophosphorus Compounds/antagonists & inhibitors; Peptide Library; Protein Engineering; Binding Sites; Chemical Warfare Agents/chemistry; Cholinesterase Inhibitors/pharmacology; Drug Evaluation, Preclinical; Models, Molecular; Molecular Structure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Computer Simulation / Protein Engineering / Chemical Warfare Agents / Cholinesterase Inhibitors / Peptide Library Language: En Journal: ACS Chem Biol Year: 2013 Document type: Article

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