Biodistribution and subcellular localization of an unnatural boron-containing amino acid (cis-ABCPC) by imaging secondary ion mass spectrometry for neutron capture therapy of melanomas and gliomas.

Chandra, Subhash; Barth, Rolf F; Haider, Syed A; Yang, Weilian; Huo, Tianyao; Shaikh, Aarif L; Kabalka, George W

Chandra, Subhash; Barth, Rolf F; Haider, Syed A; Yang, Weilian; Huo, Tianyao; Shaikh, Aarif L; Kabalka, George W.

Affiliation

Chandra S; Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America.

PLoS One ; 8(9): e75377, 2013.

Article in En | MEDLINE | ID: mdl-24058680

Subject(s)

Amino Acids; Boron Compounds; Boron Neutron Capture Therapy/methods; Brain Neoplasms; Glioma; Melanoma; Neoplasms, Experimental; Spectrometry, Mass, Secondary Ion; Amino Acids/chemical synthesis; Amino Acids/chemistry; Amino Acids/pharmacokinetics; Amino Acids/pharmacology; Animals; Blood-Brain Barrier/metabolism; Blood-Brain Barrier/pathology; Boron Compounds/chemical synthesis; Boron Compounds/chemistry; Boron Compounds/pharmacokinetics; Boron Compounds/pharmacology; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Brain Neoplasms/radiotherapy; Glioma/diagnostic imaging; Glioma/metabolism; Glioma/pathology; Humans; Male; Melanoma/metabolism; Melanoma/pathology; Melanoma/radiotherapy; Neoplasms, Experimental/metabolism; Neoplasms, Experimental/pathology; Neoplasms, Experimental/radiotherapy; Radiography; Rats; Rats, Inbred F344; S Phase/drug effects; S Phase/radiation effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Boron Compounds / Boron Neutron Capture Therapy / Spectrometry, Mass, Secondary Ion / Amino Acids / Glioma / Melanoma / Neoplasms, Experimental Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: PLoS One Year: 2013 Document type: Article

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