Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-&#945;ß and are elevated in rheumatoid arthritis.

Bekiaris, Vasileios; Sedy, John R; Rossetti, Maura; Spreafico, Roberto; Sharma, Shilpi; Rhode-Kurnow, Antje; Ware, Brian C; Huang, Nini; Macauley, Matthew G; Norris, Paula S; Albani, Salvatore; Ware, Carl F

Human CD4+CD3- innate-like T cells provide a source of TNF and lymphotoxin-αß and are elevated in rheumatoid arthritis.

Bekiaris, Vasileios; Sedy, John R; Rossetti, Maura; Spreafico, Roberto; Sharma, Shilpi; Rhode-Kurnow, Antje; Ware, Brian C; Huang, Nini; Macauley, Matthew G; Norris, Paula S; Albani, Salvatore; Ware, Carl F.

Affiliation

Bekiaris V; Infectious and Inflammatory Disease Center, Sanford|Burnham Medical Research Institute, La Jolla, CA 92037.

J Immunol ; 191(9): 4611-8, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24078690

Subject(s)

Arthritis, Rheumatoid/metabolism; CD3 Complex/metabolism; CD4-Positive T-Lymphocytes/metabolism; Lymphotoxin alpha1, beta2 Heterotrimer/metabolism; Tumor Necrosis Factors/metabolism; Adult; Aged; Animals; Arthritis, Rheumatoid/immunology; CD4-Positive T-Lymphocytes/immunology; Cell Line; Female; HEK293 Cells; Homeodomain Proteins/genetics; Humans; Inflammation; Interleukin-7/metabolism; Interleukin-7 Receptor alpha Subunit/metabolism; Lymphocyte Activation/immunology; Lymphocyte Count; Lymphotoxin alpha1, beta2 Heterotrimer/immunology; Male; Mice; Mice, Knockout; Middle Aged; Receptors, CCR6/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / CD4-Positive T-Lymphocytes / CD3 Complex / Tumor Necrosis Factors / Lymphotoxin alpha1, beta2 Heterotrimer Type of study: Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2013 Document type: Article

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