Population PKPD modeling of BACE1 inhibitor-induced reduction in Aß levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

Janson, Juliette; Eketjäll, Susanna; Tunblad, Karin; Jeppsson, Fredrik; Von Berg, Stefan; Niva, Camilla; Radesäter, Ann-Cathrin; Fälting, Johanna; Visser, Sandra A G

Janson, Juliette; Eketjäll, Susanna; Tunblad, Karin; Jeppsson, Fredrik; Von Berg, Stefan; Niva, Camilla; Radesäter, Ann-Cathrin; Fälting, Johanna; Visser, Sandra A G.

Affiliation

Janson J; Modeling & Simulation, DMPK, Innovative Medicines CNSP AstraZeneca, SE-15185, Södertälje, Sweden, juliettejanson@yahoo.com.

Pharm Res ; 31(3): 670-83, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24092053

Subject(s)

Alzheimer Disease/drug therapy; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Amyloid beta-Peptides/antagonists & inhibitors; Amyloid beta-Peptides/metabolism; Aspartic Acid Endopeptidases/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Neurons/drug effects; Alzheimer Disease/blood; Alzheimer Disease/cerebrospinal fluid; Alzheimer Disease/metabolism; Amyloid beta-Peptides/blood; Amyloid beta-Peptides/cerebrospinal fluid; Animals; Brain/cytology; Brain/drug effects; Brain/metabolism; Cell Line; Cells, Cultured; Female; Guinea Pigs; Humans; Male; Mice; Mice, Inbred C57BL; Models, Biological; Neurons/metabolism

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Amyloid beta-Peptides / Aspartic Acid Endopeptidases / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Alzheimer Disease / Neurons Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Pharm Res Year: 2014 Document type: Article

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