Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism.

Zhang, Shun; Kuang, Gang; Zhao, Guodong; Wu, Xue; Zhang, Cheng; Lei, Rongrong; Xia, Tao; Chen, Jianbin; Wang, Zhenglun; Ma, Rulin; Li, Bei; Yang, Lu; Wang, Aiguo

Zhang, Shun; Kuang, Gang; Zhao, Guodong; Wu, Xue; Zhang, Cheng; Lei, Rongrong; Xia, Tao; Chen, Jianbin; Wang, Zhenglun; Ma, Rulin; Li, Bei; Yang, Lu; Wang, Aiguo.

Affiliation

Zhang S; Department of Environmental Health and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.

Food Chem Toxicol ; 62: 699-706, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24140468

Subject(s)

Apoptosis/drug effects; Halogenated Diphenyl Ethers/toxicity; Mitochondria/drug effects; Tumor Suppressor Protein p53/metabolism; Base Sequence; Caspase 3/genetics; Caspase 3/metabolism; Cell Line, Tumor/drug effects; Cell Line, Tumor/ultrastructure; Cytochromes c/genetics; Cytochromes c/metabolism; Humans; Methylation; Mitochondria/metabolism; Mitochondria/ultrastructure; Molecular Sequence Data; Neuroblastoma/pathology; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; Tumor Suppressor Protein p53/genetics

Key words

Apoptosis; Methylation; Neurotoxicity; PBDE-47; p53 Pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Apoptosis / Halogenated Diphenyl Ethers / Mitochondria Limits: Humans Language: En Journal: Food Chem Toxicol Year: 2013 Document type: Article

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