Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo.

Du, Wen-Zhong; Feng, Yan; Wang, Xiao-Feng; Piao, Xing-Yin; Cui, Yu-Qiong; Chen, Ling-Chao; Lei, Xu-Hui; Sun, Xu; Liu, Xing; Wang, Han-Bing; Li, Xian-Feng; Yang, Dong-Bo; Sun, Ying; Zhao, Zhe-Feng; Jiang, Tao; Li, Yong-Li; Jiang, Chuan-Lu

Du, Wen-Zhong; Feng, Yan; Wang, Xiao-Feng; Piao, Xing-Yin; Cui, Yu-Qiong; Chen, Ling-Chao; Lei, Xu-Hui; Sun, Xu; Liu, Xing; Wang, Han-Bing; Li, Xian-Feng; Yang, Dong-Bo; Sun, Ying; Zhao, Zhe-Feng; Jiang, Tao; Li, Yong-Li; Jiang, Chuan-Lu.

Affiliation

Du WZ; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

CNS Neurosci Ther ; 19(12): 926-36, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24165291

Subject(s)

Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Brain Neoplasms/drug therapy; Curcumin/therapeutic use; Glioma/drug therapy; Signal Transduction/drug effects; Animals; Brain Neoplasms/metabolism; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Colony-Forming Units Assay; Disease Models, Animal; Glioma/metabolism; Hedgehog Proteins/metabolism; Humans; Kaplan-Meier Estimate; Mice; Transcription Factors/metabolism; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1

Key words

Apoptosis; Curcumin; GLI1; Malignant glioma; Proliferation

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Brain Neoplasms / Signal Transduction / Apoptosis / Curcumin / Glioma / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: CNS Neurosci Ther Year: 2013 Document type: Article

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