G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.

Majumder, Syamantak; Sowden, Mark P; Gerber, Scott A; Thomas, Tamlyn; Christie, Christine K; Mohan, Amy; Yin, Guoyong; Lord, Edith M; Berk, Bradford C; Pang, Jinjiang

Majumder, Syamantak; Sowden, Mark P; Gerber, Scott A; Thomas, Tamlyn; Christie, Christine K; Mohan, Amy; Yin, Guoyong; Lord, Edith M; Berk, Bradford C; Pang, Jinjiang.

Affiliation

Majumder S; From the Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY (S.M., M.P.S., T.T., C.K.C., A.M. G.Y., B.C.B., J.P.); and Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY (S.A.G., E.M.L.).

Arterioscler Thromb Vasc Biol ; 34(2): 419-26, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24265417

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cell Cycle Proteins/metabolism; Cell Movement; Cortactin/metabolism; GTPase-Activating Proteins/metabolism; Human Umbilical Vein Endothelial Cells/metabolism; Melanoma, Experimental/metabolism; Neovascularization, Pathologic; Neovascularization, Physiologic; Pseudopodia/metabolism; Soft Tissue Neoplasms/metabolism; Adaptor Proteins, Signal Transducing/genetics; Animals; Cell Cycle Proteins/deficiency; Cell Cycle Proteins/genetics; Cortactin/genetics; GTPase-Activating Proteins/deficiency; GTPase-Activating Proteins/genetics; HEK293 Cells; Humans; Melanoma, Experimental/blood supply; Melanoma, Experimental/genetics; Melanoma, Experimental/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation; Protein Interaction Domains and Motifs; RNA Interference; Signal Transduction; Soft Tissue Neoplasms/blood supply; Soft Tissue Neoplasms/genetics; Soft Tissue Neoplasms/pathology; Time Factors; Transfection; Tumor Burden; Vascular Endothelial Growth Factor A/metabolism; cdc42 GTP-Binding Protein/metabolism; rac1 GTP-Binding Protein/metabolism

Key words

G-proteincoupled receptor kinase; cortactin; endothelial cells; interacting protein-1; tumor angiogenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudopodia / Soft Tissue Neoplasms / Melanoma, Experimental / Cell Movement / Cell Cycle Proteins / Neovascularization, Physiologic / GTPase-Activating Proteins / Adaptor Proteins, Signal Transducing / Cortactin / Human Umbilical Vein Endothelial Cells Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Arterioscler Thromb Vasc Biol Year: 2014 Document type: Article

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