Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML.

Mak, P Y; Mak, D H; Mu, H; Shi, Y; Ruvolo, P; Ruvolo, V; Jacamo, R; Burks, J K; Wei, W; Huang, X; Kornblau, S M; Andreeff, M; Carter, B Z

Mak, P Y; Mak, D H; Mu, H; Shi, Y; Ruvolo, P; Ruvolo, V; Jacamo, R; Burks, J K; Wei, W; Huang, X; Kornblau, S M; Andreeff, M; Carter, B Z.

Affiliation

Mak PY; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Apoptosis ; 19(4): 698-707, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24337870

Subject(s)

Caspases/metabolism; Cytoskeletal Proteins/metabolism; Leukemia, Myeloid, Acute/metabolism; Mitogen-Activated Protein Kinases/metabolism; Nerve Tissue Proteins/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Animals; Antimetabolites, Antineoplastic/pharmacology; Apoptosis/drug effects; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytarabine/pharmacology; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/pathology; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Signal Transduction

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Full text: 1 Collection: 01-internacional Health context: 4_TD / 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Phosphatidylinositol 3-Kinases / Caspases / Mitogen-Activated Protein Kinases / Cytoskeletal Proteins / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Apoptosis Year: 2014 Document type: Article

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