Synthesis of single-enantiomer bioactive molecules: a brief overview.
Chirality
; 26(2): 63-78, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-24339171
ABSTRACT
Chiral-center enantiomers have been shown to differ significantly in biological activity, pharmacodynamics, pharmacokinetics and toxicity. New developments in the stereoselective organic synthesis have enriched the vast literature of synthetic methodologies applicable to access natural products as well as bioactive molecules. These compounds also include new drugs, drug candidates and reagents used to explore biological processes. The article reviews the synthesis of optically pure drugs, biologically active intermediates and amino alcohols by using different methods.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Design
/
Amino Alcohols
Language:
En
Journal:
Chirality
Year:
2014
Document type:
Article