Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.

Lundquist, Patrik; Lööf, Johan; Fagerholm, Urban; Sjögren, Ingemo; Johansson, Jenny; Briem, Sveinn; Hoogstraate, Janet; Afzelius, Lovisa; Andersson, Tommy B

Lundquist, Patrik; Lööf, Johan; Fagerholm, Urban; Sjögren, Ingemo; Johansson, Jenny; Briem, Sveinn; Hoogstraate, Janet; Afzelius, Lovisa; Andersson, Tommy B.

Affiliation

Lundquist P; CNS and Pain Innovative Medicines DMPK, AstraZeneca R&D, Södertälje (P.L., J.L., U.F., I.S., J.J., S.B., J.H., L.A.); Cardiovascular and Metabolic Diseases Innovative Medicines DMPK, AstraZeneca R&D, Mölndal (P.L., T.B.A.); Department of Pharmacy, Uppsala University, Uppsala (P.L.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (T.B.A.), Sweden.

Drug Metab Dispos ; 42(3): 459-68, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24396143

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Bile/metabolism; Hepatocytes/metabolism; Models, Biological; Pharmaceutical Preparations/metabolism; Animals; Blood Proteins/metabolism; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 Enzyme System/metabolism; Hepatocytes/drug effects; Hepatocytes/enzymology; Male; Metabolic Clearance Rate; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Predictive Value of Tests; Protein Binding; Rats; Rats, Sprague-Dawley; Substrate Specificity; Tandem Mass Spectrometry; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile / Pharmaceutical Preparations / ATP-Binding Cassette Transporters / Hepatocytes / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Drug Metab Dispos Year: 2014 Document type: Article

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