Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticles with polyethylenimine coat as simple, safe, and versatile vehicles for cell targeting: population characteristics, cell uptake, and intracellular trafficking.
Adv Healthc Mater
; 3(6): 817-24, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24408356
ABSTRACT
A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethyleneimine
/
Caproates
/
3-Hydroxybutyric Acid
/
Nanoparticles
Limits:
Humans
Language:
En
Journal:
Adv Healthc Mater
Year:
2014
Document type:
Article