The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.

Perli, Elena; Giordano, Carla; Pisano, Annalinda; Montanari, Arianna; Campese, Antonio F; Reyes, Aurelio; Ghezzi, Daniele; Nasca, Alessia; Tuppen, Helen A; Orlandi, Maurizia; Di Micco, Patrizio; Poser, Elena; Taylor, Robert W; Colotti, Gianni; Francisci, Silvia; Morea, Veronica; Frontali, Laura; Zeviani, Massimo; d'Amati, Giulia

Perli, Elena; Giordano, Carla; Pisano, Annalinda; Montanari, Arianna; Campese, Antonio F; Reyes, Aurelio; Ghezzi, Daniele; Nasca, Alessia; Tuppen, Helen A; Orlandi, Maurizia; Di Micco, Patrizio; Poser, Elena; Taylor, Robert W; Colotti, Gianni; Francisci, Silvia; Morea, Veronica; Frontali, Laura; Zeviani, Massimo; d'Amati, Giulia.

Affiliation

Perli E; Department of Radiology, Oncology and Pathology, Sapienza University of Rome, Rome, Italy.

EMBO Mol Med ; 6(2): 169-82, 2014 02.

Article in En | MEDLINE | ID: mdl-24413190

Subject(s)

Amino Acyl-tRNA Synthetases/chemistry; Amino Acyl-tRNA Synthetases/metabolism; Mitochondria/enzymology; Mitochondria/genetics; Mutation/genetics; RNA, Transfer, Leu/genetics; Cell Survival; Energy Metabolism; Humans; Peptides/metabolism; Phenotype; Protein Binding; Protein Structure, Tertiary; Protein Transport

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Transfer, Leu / Amino Acyl-tRNA Synthetases / Mitochondria / Mutation Limits: Humans Language: En Journal: EMBO Mol Med Year: 2014 Document type: Article

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