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Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition.
Morikawa, Hiroshi; Tomishima, Masaki; Kayakiri, Natsuko; Araki, Takanobu; Barrett, David; Akamatsu, Souichirou; Matsumoto, Satoru; Uchida, Satoko; Nakai, Toru; Takeda, Shinobu; Maki, Katsuyuki.
Affiliation
  • Morikawa H; Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroshi.morikawa@astellas.com.
  • Tomishima M; Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Kayakiri N; Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Araki T; Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Barrett D; Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Akamatsu S; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Matsumoto S; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Uchida S; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Nakai T; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Takeda S; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
  • Maki K; Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Bioorg Med Chem Lett ; 24(4): 1172-5, 2014 Feb 15.
Article in En | MEDLINE | ID: mdl-24468413
ABSTRACT
The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspergillus / Echinocandins / Antifungal Agents Language: En Journal: Bioorg Med Chem Lett Year: 2014 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspergillus / Echinocandins / Antifungal Agents Language: En Journal: Bioorg Med Chem Lett Year: 2014 Document type: Article