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Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.
Yang, F; Deng, R; Qian, X-J; Chang, S-H; Wu, X-Q; Qin, J; Feng, G-K; Ding, K; Zhu, X-F.
Affiliation
  • Yang F; 1] State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China [2] Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.
  • Deng R; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Qian XJ; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Chang SH; 1] Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China [2] Graduate School, Chinese Academy of Sciences, Beijing, China.
  • Wu XQ; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Qin J; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Feng GK; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Ding K; 1] Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China [2] Graduate School, Chinese Academy of Sciences, Beijing, China.
  • Zhu XF; State Key Laboratory of Oncology in South China, Collaborative Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Cell Death Dis ; 5: e1114, 2014 Mar 13.
Article in En | MEDLINE | ID: mdl-24625973
Subject(s)
Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Liver Neoplasms/drug therapy; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Pyrimidines/pharmacology; Thiazoles/pharmacology; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Animals; Calcium Signaling/drug effects; Calmodulin/metabolism; Cell Cycle Proteins; Cell Proliferation/drug effects; Class III Phosphatidylinositol 3-Kinases/genetics; Class III Phosphatidylinositol 3-Kinases/metabolism; Dose-Response Relationship, Drug; Feedback, Physiological; Hep G2 Cells; Humans; Liver Neoplasms/enzymology; Liver Neoplasms/genetics; Liver Neoplasms/pathology; MAP Kinase Signaling System/drug effects; Mechanistic Target of Rapamycin Complex 1; Mice, Nude; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases/metabolism; Multiprotein Complexes/antagonists & inhibitors; Multiprotein Complexes/genetics; Multiprotein Complexes/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-raf/metabolism; RNA Interference; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/genetics; TOR Serine-Threonine Kinases/metabolism; Time Factors; Transfection; Tumor Burden/drug effects; Xenograft Model Antitumor Assays
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiazoles / Apoptosis / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Liver Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Cell Death Dis Year: 2014 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Thiazoles / Apoptosis / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Liver Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Cell Death Dis Year: 2014 Document type: Article