Functional intersection of Human Defensin 5 with the TNF receptor pathway.
FEBS Lett
; 588(10): 1906-12, 2014 May 21.
Article
in En
| MEDLINE
| ID: mdl-24681099
ABSTRACT
Defensins are cationic antimicrobial peptides that contribute to regulation of host cell function also. Here, we report on the regulation of cell death by Human Defensin 5, the major antimicrobial peptide of ileal Paneth cells. We find that Human Defensin 5-mediated cellular effects depend on functional expression of Tumor Necrosis Factor receptors and downstream mediators of TNF signaling. Our data indicate the involvement of interactions between Human Defensin 5 and the extra-cellular domain of Tumor Necrosis Factor receptor 1. Human Defensin-5 also induces apoptosis intrinsically by targeting the mitochondrial membrane.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Defensins
/
Alpha-Defensins
/
Receptors, Tumor Necrosis Factor, Type I
/
Macrophages
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS Lett
Year:
2014
Document type:
Article