In cell scalaradial interactome profiling using a bio-orthogonal clickable probe.
Chem Commun (Camb)
; 50(45): 6043-5, 2014 Jun 07.
Article
in En
| MEDLINE
| ID: mdl-24769547
ABSTRACT
A bio-orthogonal click-chemistry procedure was developed to allow the in cell interactome profiling of scalaradial, an anti-inflammatory marine natural product. The results were validated through the application of the classical in vitro chemical proteomics and several bio-physical methods; peroxiredoxins, 14-3-3 isoforms and proteasomes were recognized as main scalaradial targets.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
14-3-3 Proteins
/
Sesterterpenes
/
Peroxiredoxins
/
Click Chemistry
/
Homosteroids
/
Anti-Inflammatory Agents
Limits:
Humans
Language:
En
Journal:
Chem Commun (Camb)
Year:
2014
Document type:
Article