Exposure vs. response of blood pressure in patients with rheumatoid arthritis following treatment with fostamatinib.

Boström, Emma; Öhrn, Fredrik; Hanze, Eva; Sandström, Marie; Martin, Paul; Wählby-Hamrén, Ulrika

Boström, Emma; Öhrn, Fredrik; Hanze, Eva; Sandström, Marie; Martin, Paul; Wählby-Hamrén, Ulrika.

Affiliation

Boström E; AstraZeneca R&D, Södertälje, Sweden.

J Clin Pharmacol ; 54(12): 1337-46, 2014 Dec.

Article in En | MEDLINE | ID: mdl-24895144

Subject(s)

Antirheumatic Agents/pharmacology; Antirheumatic Agents/pharmacokinetics; Blood Pressure/drug effects; Models, Biological; Oxazines/pharmacology; Oxazines/pharmacokinetics; Pyridines/pharmacology; Pyridines/pharmacokinetics; Adolescent; Adult; Aged; Aged, 80 and over; Aminopyridines; Antirheumatic Agents/blood; Antirheumatic Agents/therapeutic use; Arthritis, Rheumatoid/drug therapy; Arthritis, Rheumatoid/metabolism; Arthritis, Rheumatoid/physiopathology; Double-Blind Method; Female; Humans; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Male; Middle Aged; Morpholines; Oxazines/blood; Oxazines/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyridines/blood; Pyridines/therapeutic use; Pyrimidines; Syk Kinase; Young Adult

Key words

NONMEM; PKPD; blood pressure; fostamatinib; population pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Pyridines / Blood Pressure / Antirheumatic Agents / Models, Biological Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2014 Document type: Article

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