Placental weight and foetal growth rate as predictors of ischaemic heart disease in a Swedish cohort.
J Dev Orig Health Dis
; 5(3): 164-70, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24901654
ABSTRACT
Studies on placental size and cardiovascular disease have shown inconsistent results. We followed 10,503 men and women born in Uppsala, Sweden, 1915-1929 from 1964 to 2008 to assess whether birth characteristics, including placental weight and placenta/birth weight ratio, were predictive of future ischaemic heart disease (IHD). Adjustments were made for birth cohort, age, sex, mother's parity, birth weight, gestational age and social class at birth. Placental weight and birth weight were negatively associated with IHD. The effect of placental weight on IHD was stronger in individuals from medium social class at birth and in those with low education. Men and women from non-manual social class at birth had the lowest risk for IHD as adults. We conclude that low foetal growth rate rather than placental weight was more predictive of IHD in the Swedish cohort. However, the strong effect of social class at birth on risk for IHD did not appear to be mediated by foetal growth rate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placentation
/
Social Class
/
Birth Weight
/
Myocardial Ischemia
/
Fetal Development
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
/
Patient_preference
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
J Dev Orig Health Dis
Year:
2014
Document type:
Article