Genetic polymorphisms of CYP2E1 and GSTM1 loci and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.

Sharma, S K; Jha, B K; Sharma, A; Sreenivas, V; Upadhyay, V; Jaisinghani, C; Singla, R; Mishra, H K; Soneja, M

Sharma, S K; Jha, B K; Sharma, A; Sreenivas, V; Upadhyay, V; Jaisinghani, C; Singla, R; Mishra, H K; Soneja, M.

Affiliation

Sharma SK; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Jha BK; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Sharma A; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Sreenivas V; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Upadhyay V; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Jaisinghani C; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Singla R; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Mishra HK; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Soneja M; Departments of Internal Medicine, and Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Int J Tuberc Lung Dis ; 18(5): 588-93, 2014 May.

Article in En | MEDLINE | ID: mdl-24903797

Subject(s)

Antitubercular Agents/adverse effects; Chemical and Drug Induced Liver Injury/enzymology; Chemical and Drug Induced Liver Injury/genetics; Cytochrome P-450 CYP2E1/genetics; Glutathione Transferase/genetics; Mutation; Polymorphism, Genetic; 5' Untranslated Regions; Adolescent; Adult; Aged; Case-Control Studies; Chemical and Drug Induced Liver Injury/diagnosis; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; India; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Prospective Studies; Risk Factors; Young Adult

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 3_ND Database: MEDLINE Main subject: Polymorphism, Genetic / Cytochrome P-450 CYP2E1 / Chemical and Drug Induced Liver Injury / Glutathione Transferase / Mutation / Antitubercular Agents Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Int J Tuberc Lung Dis Year: 2014 Document type: Article

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