Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 24(14): 3092-5, 2014 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-24907145
ABSTRACT
The first synthesis of 1'-cyano-2'-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1'-unsubstituted counterparts and to the related 1'-cyano-2'-C-methyl C-nucleoside parent of GS-6620.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pyrimidine Nucleosides
/
RNA-Dependent RNA Polymerase
/
Viral Nonstructural Proteins
/
Hepacivirus
/
Enzyme Inhibitors
/
Nucleosides
Language:
En
Journal:
Bioorg Med Chem Lett
Year:
2014
Document type:
Article