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Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
Mish, Michael R; Cho, Aesop; Kirschberg, Thorsten; Xu, Jie; Zonte, C Sebastian; Fenaux, Martijn; Park, Yeojin; Babusis, Darius; Feng, Joy Y; Ray, Adrian S; Kim, Choung U.
Affiliation
  • Mish MR; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA. Electronic address: mmish@gilead.com.
  • Cho A; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Kirschberg T; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Xu J; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Zonte CS; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Fenaux M; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Park Y; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Babusis D; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Feng JY; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Ray AS; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
  • Kim CU; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, CA 94044, USA.
Bioorg Med Chem Lett ; 24(14): 3092-5, 2014 Jul 15.
Article in En | MEDLINE | ID: mdl-24907145
ABSTRACT
The first synthesis of 1'-cyano-2'-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1'-unsubstituted counterparts and to the related 1'-cyano-2'-C-methyl C-nucleoside parent of GS-6620.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrimidine Nucleosides / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors / Nucleosides Language: En Journal: Bioorg Med Chem Lett Year: 2014 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrimidine Nucleosides / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors / Nucleosides Language: En Journal: Bioorg Med Chem Lett Year: 2014 Document type: Article