The role of hypoxia-inducible factors in organ donation and transplantation: the current perspective and future opportunities.
Am J Transplant
; 14(7): 1481-7, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-24909061
Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors that activate a number of hypoxia responsive genes, some of which are responsible for protective cellular functions. During organ donation, allografts are exposed to significant periods of hypoxia and ischemia. Exploiting this pathway during donor management and organ preservation could prevent and reduce allograft injury and improve the outcomes of organ transplantation. We review the evidence on this pathway in organ preservation, drawing on experimental studies on donor management and ischemia reperfusion injury focusing on kidney, liver, cardiac and lung transplantation. We review the major technical and experimental challenges in exploring this pathway and suggest potential future avenues for research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organ Preservation
/
Tissue and Organ Procurement
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Reperfusion Injury
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Organ Transplantation
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Hypoxia-Inducible Factor 1
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Hypoxia
Limits:
Humans
Language:
En
Journal:
Am J Transplant
Year:
2014
Document type:
Article