Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae.

Lu, Zhao-Guang; Li, Ming-Hui; Wang, Jun-Song; Wei, Dan-Dan; Liu, Qing-Wang; Kong, Ling-Yi

Lu, Zhao-Guang; Li, Ming-Hui; Wang, Jun-Song; Wei, Dan-Dan; Liu, Qing-Wang; Kong, Ling-Yi.

Affiliation

Lu ZG; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Li MH; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Wang JS; Center for Molecular Metabolism, School of Environmental & Biological Engineering, Nanjing University of Science & Technology, 200 Xiao Ling Wei Street, Nanjing 210094, PR China. Electronic address: wang.junsong@gmail.com.
Wei DD; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Liu QW; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Kong LY; State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: cpu_lykong@126.com.

Reprod Toxicol ; 47: 33-41, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24911943

Subject(s)

Alkaloids/toxicity; Cardiotoxins/toxicity; Neurotoxins/toxicity; Quinolizines/toxicity; Teratogens/toxicity; Animals; Behavior, Animal/drug effects; Embryo, Nonmammalian/abnormalities; Embryo, Nonmammalian/drug effects; Embryonic Development/drug effects; Heart Rate/drug effects; Motor Activity/drug effects; Myocardium/pathology; Notochord/abnormalities; Tail/abnormalities; Zebrafish/abnormalities; Matrines

Key words

Developmental toxicity; Matrine; Neurotoxicity; Sophocarpine; Spontaneous movement; Swimming behavior; Zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolizines / Teratogens / Alkaloids / Cardiotoxins / Neurotoxins Limits: Animals Language: En Journal: Reprod Toxicol Year: 2014 Document type: Article

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