Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

Kowalski, M; Hausmann, R; Dopychai, A; Grohmann, M; Franke, H; Nieber, K; Schmalzing, G; Illes, P; Riedel, T

Kowalski, M; Hausmann, R; Dopychai, A; Grohmann, M; Franke, H; Nieber, K; Schmalzing, G; Illes, P; Riedel, T.

Affiliation

Kowalski M; Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany.

Br J Pharmacol ; 171(22): 5093-112, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24989924

Subject(s)

Adenosine Triphosphate/analogs & derivatives; Models, Molecular; Purinergic P2X Receptor Agonists/pharmacology; Receptors, Purinergic P2X3; Adenosine Triphosphate/pharmacology; Animals; HEK293 Cells; Humans; Ion Channel Gating; Mutation; Oocytes; Protein Conformation; Receptors, Purinergic P2X3/chemistry; Receptors, Purinergic P2X3/genetics; Receptors, Purinergic P2X3/physiology; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Adenosine Triphosphate / Receptors, Purinergic P2X3 / Purinergic P2X Receptor Agonists Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2014 Document type: Article

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