Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, ß-arrestin translocation and chemotaxis assays.

Gilchrist, A; Gauntner, T D; Fazzini, A; Alley, K M; Pyen, D S; Ahn, J; Ha, S J; Willett, A; Sansom, S E; Yarfi, J L; Bachovchin, K A; Mazzoni, M R; Merritt, J R

Gilchrist, A; Gauntner, T D; Fazzini, A; Alley, K M; Pyen, D S; Ahn, J; Ha, S J; Willett, A; Sansom, S E; Yarfi, J L; Bachovchin, K A; Mazzoni, M R; Merritt, J R.

Affiliation

Gilchrist A; Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA.

Br J Pharmacol ; 171(22): 5127-38, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24990525

Subject(s)

Receptors, CCR1/antagonists & inhibitors; Receptors, CCR1/metabolism; Animals; Arrestins/metabolism; CHO Cells; Cell Line, Tumor; Chemokine CCL3/metabolism; Chemotaxis; Cricetulus; HEK293 Cells; Humans; Multiple Myeloma; Phenylurea Compounds/pharmacology; Piperidines/pharmacology; Quinoxalines/pharmacology; Radioligand Assay; Spiro Compounds/pharmacology; beta-Arrestins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, CCR1 Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2014 Document type: Article

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