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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.
Eiring, Anna M; Page, Brent D G; Kraft, Ira L; Mason, Clinton C; Vellore, Nadeem A; Resetca, Diana; Zabriskie, Matthew S; Zhang, Tian Y; Khorashad, Jamshid S; Engar, Alexander J; Reynolds, Kimberly R; Anderson, David J; Senina, Anna; Pomicter, Anthony D; Arpin, Carolynn C; Ahmad, Shazia; Heaton, William L; Tantravahi, Srinivas K; Todic, Aleksandra; Moriggl, Richard; Wilson, Derek J; Baron, Riccardo; O'Hare, Thomas; Gunning, Patrick T; Deininger, Michael W.
Affiliation
  • Eiring AM; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Page BDG; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
  • Kraft IL; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Mason CC; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Vellore NA; Department of Medicinal Chemistry, College of Pharmacy, The University of Utah, Salt Lake City, Utah, USA.
  • Resetca D; York University Chemistry Department, Toronto, Ontario, Canada.
  • Zabriskie MS; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Zhang TY; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Khorashad JS; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Engar AJ; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Reynolds KR; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Anderson DJ; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Senina A; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Pomicter AD; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Arpin CC; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
  • Ahmad S; Department of Medicinal Chemistry, College of Pharmacy, The University of Utah, Salt Lake City, Utah, USA.
  • Heaton WL; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Tantravahi SK; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Todic A; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
  • Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
  • Wilson DJ; York University Chemistry Department, Toronto, Ontario, Canada.
  • Baron R; Center for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario, Canada.
  • O'Hare T; Department of Medicinal Chemistry, College of Pharmacy, The University of Utah, Salt Lake City, Utah, USA.
  • Gunning PT; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA.
  • Deininger MW; Division of Hematology and Hematologic Malignancies, The University of Utah, Salt Lake City, Utah, USA.
Leukemia ; 29(3): 586-597, 2015 Mar.
Article in En | MEDLINE | ID: mdl-25134459
Subject(s)
Aminosalicylic Acids/pharmacology; Fusion Proteins, bcr-abl/genetics; Gene Expression Regulation, Leukemic; Leukocytes, Mononuclear/drug effects; Neoplastic Stem Cells/drug effects; STAT3 Transcription Factor/genetics; Small Molecule Libraries/pharmacology; Sulfonamides/pharmacology; Aminosalicylic Acids/chemical synthesis; Aminosalicylic Acids/chemistry; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Benzamides/pharmacology; Cell Line, Tumor; Dasatinib; Drug Discovery; Drug Resistance, Neoplasm/drug effects; Fusion Proteins, bcr-abl/antagonists & inhibitors; Fusion Proteins, bcr-abl/metabolism; Genes, Reporter; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Leukocytes, Mononuclear/metabolism; Leukocytes, Mononuclear/pathology; Luciferases/genetics; Luciferases/metabolism; Molecular Docking Simulation; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Phosphorylation; Piperazines/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary; Pyrimidines/pharmacology; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/chemistry; STAT3 Transcription Factor/metabolism; Signal Transduction; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry; Sulfonamides/chemical synthesis; Sulfonamides/chemistry; Thiazoles/pharmacology
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Sulfonamides / Neoplastic Stem Cells / Leukocytes, Mononuclear / Gene Expression Regulation, Leukemic / Fusion Proteins, bcr-abl / STAT3 Transcription Factor / Small Molecule Libraries / Aminosalicylic Acids Type of study: Prognostic_studies Language: En Journal: Leukemia Year: 2015 Document type: Article
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Sulfonamides / Neoplastic Stem Cells / Leukocytes, Mononuclear / Gene Expression Regulation, Leukemic / Fusion Proteins, bcr-abl / STAT3 Transcription Factor / Small Molecule Libraries / Aminosalicylic Acids Type of study: Prognostic_studies Language: En Journal: Leukemia Year: 2015 Document type: Article