Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients.

Mauri, Pierluigi; Riccio, Anna Maria; Rossi, Rossana; Di Silvestre, Dario; Benazzi, Louise; De Ferrari, Laura; Dal Negro, Roberto Walter; Holgate, Stephen T; Canonica, Giorgio Walter

Mauri, Pierluigi; Riccio, Anna Maria; Rossi, Rossana; Di Silvestre, Dario; Benazzi, Louise; De Ferrari, Laura; Dal Negro, Roberto Walter; Holgate, Stephen T; Canonica, Giorgio Walter.

Affiliation

Mauri P; Institute for Biomedical Technologies (ITB-CNR), Milan, Italy.
Riccio AM; Allergy and Respiratory Diseases Unit, Dpt. of Internal Medicine, University of Genoa, IRCCS-IST AOU San Martino, Genoa, Italy.
Rossi R; Institute for Biomedical Technologies (ITB-CNR), Milan, Italy.
Di Silvestre D; Institute for Biomedical Technologies (ITB-CNR), Milan, Italy.
Benazzi L; Institute for Biomedical Technologies (ITB-CNR), Milan, Italy.
De Ferrari L; Allergy and Respiratory Diseases Unit, Dpt. of Internal Medicine, University of Genoa, IRCCS-IST AOU San Martino, Genoa, Italy.
Dal Negro RW; CMS, Verona, Italy.
Holgate ST; Inflammation, Infection and Immunity Division, Sir Henry Wellcome Laboratories, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton SO16 6YD, UK.
Canonica GW; Allergy and Respiratory Diseases Unit, Dpt. of Internal Medicine, University of Genoa, IRCCS-IST AOU San Martino, Genoa, Italy. Electronic address: canonica@unige.it.

Immunol Lett ; 162(1 Pt A): 2-10, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25194755

Subject(s)

Asthma/metabolism; Asthma/pathology; Bronchi/metabolism; Bronchi/pathology; Proteome; Proteomics; Adult; Airway Remodeling; Anti-Asthmatic Agents/therapeutic use; Antibodies, Anti-Idiotypic/therapeutic use; Antibodies, Monoclonal, Humanized/therapeutic use; Asthma/drug therapy; Biomarkers/metabolism; Biopsy; Cluster Analysis; Female; Galectin 3/metabolism; Humans; Immunohistochemistry; Male; Middle Aged; Odds Ratio; Omalizumab; Prognosis; Protein Interaction Maps; Severity of Illness Index; Treatment Outcome

Key words

Galectin-3; Interactome; Omalizumab; Proteomics analysis; Severe asthma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Bronchi / Proteome / Proteomics Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Immunol Lett Year: 2014 Document type: Article

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