Outcomes after liver transplantation of patients with Indo-Asian ethnicity.
Transplantation
; 99(4): 860-6, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-25211517
ABSTRACT
BACKGROUND:
The impact of ethnicity on outcomes after orthotopic liver transplantation (OLT) is unclear. The British Indo-Asian population has a high incidence of liver disease but its contribution to the national deceased donor pool is small. We evaluated access to and outcomes of OLT in Indo-Asians.METHODS:
We compared 182 Indo-Asians with white patients undergoing OLT. Matching criteria were transplantation year, liver disease, age, sex. Donor and recipient characteristics, postoperative outcomes, including patient and graft survival, OLT era (early, 1987-2001; late, 2002-2011) were compared. Survival was also analyzed by underlying disease-acute liver failure (ALF) and chronic liver failure.RESULTS:
Indo-Asians had higher diabetes incidence. There were no differences in waiting time for transplantation, despite smaller body size and more uncommon blood groups (B, AB) among Indo-Asians. In the early era, patient survival for Indo-Asians with ALF was worse when compared to whites. In the late era, graft and patient survival at 1, 2, and 5 years were similar between groups.CONCLUSION:
This study demonstrates that Indo-Asian patients have equal access to OLT and comparable outcomes to whites in the United Kingdom. Survival has improved among Indo-Asian patients; this may be attributable to careful patient selection in case of ALF, though improvement of patient management may have contributed.
Full text:
1
Collection:
01-internacional
Topics:
Promover_ampliacao_atencao_especializada
Health context:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Liver Transplantation
/
Liver Failure, Acute
/
Asian People
/
End Stage Liver Disease
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Aspects:
Determinantes_sociais_saude
Country/Region as subject:
Asia
/
Europa
Language:
En
Journal:
Transplantation
Year:
2015
Document type:
Article