Labdane diterpenoids from Salvia reuterana.
Phytochemistry
; 108: 264-9, 2014 Dec.
Article
in En
| MEDLINE
| ID: mdl-25236692
ABSTRACT
Three labdane diterpenoids, 14α-hydroxy-15-chlorosclareol (1), 14α-hydroxy-15-acetoxysclareol (2), and 6ß-hydroxy-14α-epoxysclareol (3), together with the known diterpenoids sclareol (4), 6ß-hydroxysclareol (5), and 14α-epoxysclareol (6), as well as other common plant constituents were isolated from the n-hexane extract of aerial parts of Salvia reuterana. The structures of the new compounds were established by extensive 1D and 2D NMR spectroscopic techniques. Compound 1 is the first example of a halogenated terpenoid in the genus Salvia. Compounds 1-6 were also tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Preliminary structure-activity relationship studies indicated that double bond moiety in sclareol is an essential feature for activity and modification of this moiety significantly decreased the cytotoxic activity of the resulting compounds.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diterpenes
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Phytochemistry
Year:
2014
Document type:
Article