Globozoospermia syndrome: two case reports.

Globozoospermia is a rare but severe cause of male infertility. The presence of 100% round-headed spermatozoa and lack of acrosome are the diagnostic criteria of total globozoospermia. The pathogenesis of globozoospermia most probably originates in spermiogenesis, specifically in acrosome formation and sperm head elongation. Mutations of a numbers of genes are linked to the globozoospermic phenotype. Intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation improves the fertilization rate of these cases. Two cases of globozoospermia with infertility are presented in this study.