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A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials.
Doussau, A; Thiébaut, R; Geoerger, B; Schöffski, P; Floquet, A; Le Deley, M C; Mathoulin-Pélissier, S; Rizzo, E; Fumoleau, P; Le Tourneau, C; Paoletti, X.
Affiliation
  • Doussau A; Department of Biostatistics, Institut Curie, Paris U900, INSERM, Paris CIC1401-Clinical Epidemiology, INSERM U897, Bordeaux Division of Public Health, University Hospital, Bordeaux CIC1401-Clinical Epidemiology, Bordeaux University, Bordeaux adelaide.doussau@isped.u-bordeaux2.fr.
  • Thiébaut R; CIC1401-Clinical Epidemiology, INSERM U897, Bordeaux Division of Public Health, University Hospital, Bordeaux CIC1401-Clinical Epidemiology, Bordeaux University, Bordeaux Labex Vaccine Research Institute, Bordeaux.
  • Geoerger B; Pediatric and Adolescent Oncology, Institut Gustave Roussy, Villejuif CNRS UMR8203, University Paris-Sud 11, Villejuif, France.
  • Schöffski P; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Floquet A; CIC1401-Clinical Epidemiology, Institut Bergonié, Bordeaux.
  • Le Deley MC; Biostatistics and Epidemiology Unit, Institut Gustave Roussy, University Paris-Sud 11, Villejuif, France.
  • Mathoulin-Pélissier S; CIC1401-Clinical Epidemiology, Bordeaux University, Bordeaux CIC1401-Clinical Epidemiology, Institut Bergonié, Bordeaux.
  • Rizzo E; EORTC-Headquarter, Brussels, Belgium.
  • Fumoleau P; Comprehensive Cancer Center, Centre Georges-François Leclerc, Dijon.
  • Le Tourneau C; U900, INSERM, Paris Department of Medical Oncology, Institut Curie, Paris and Saint-Cloud, France.
  • Paoletti X; Department of Biostatistics, Institut Curie, Paris U900, INSERM, Paris.
Ann Oncol ; 26(2): 422-8, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25403589
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Statistical / Clinical Trials, Phase I as Topic / Maximum Tolerated Dose / Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ann Oncol Year: 2015 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Statistical / Clinical Trials, Phase I as Topic / Maximum Tolerated Dose / Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ann Oncol Year: 2015 Document type: Article