The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches.

Sainath, Rajiv; Gallo, Gianluca

Sainath, Rajiv; Gallo, Gianluca.

Affiliation

Sainath R; Department of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, 3500 N Broad St, Philadelphia, Pennsylvania, 19140.
Gallo G; Department of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, 3500 N Broad St, Philadelphia, Pennsylvania, 19140.

Dev Neurobiol ; 75(7): 757-77, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25404503

Subject(s)

Axons/drug effects; Dyneins/antagonists & inhibitors; Growth Cones/drug effects; Organelles/drug effects; Quinazolinones/pharmacology; Sensory Receptor Cells/drug effects; Actin Cytoskeleton/drug effects; Actin Cytoskeleton/metabolism; Animals; Axons/physiology; Biological Transport/drug effects; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Cells, Cultured; Chick Embryo; Cytoplasm/drug effects; Cytoplasm/metabolism; Dyneins/metabolism; Ganglia, Spinal/drug effects; Ganglia, Spinal/physiology; Growth Cones/physiology; Nerve Growth Factor/metabolism; Organelles/metabolism; Sensory Receptor Cells/physiology; Thiazolidines/pharmacology; Tissue Culture Techniques; Wallerian Degeneration/metabolism

Key words

Ciliobrevin D; Golgi derived vesicles; Wallerian degeneration; axon branching; axon growth; axon transport; dynein; kinesin; latrunculin; lysosome; mitochondria; p150glued dynactin; tubulin acetylation; tubulin tyrosination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensory Receptor Cells / Axons / Organelles / Dyneins / Growth Cones / Quinazolinones Type of study: Prognostic_studies Limits: Animals Language: En Journal: Dev Neurobiol Year: 2015 Document type: Article

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