Testicular germ cell tumors in adolescents - results of the protocol MAHO 98 and the identification of good risk patients.
Klin Padiatr
; 226(6-7): 316-22, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25431864
ABSTRACT
BACKGROUND:
In adolescents aged 10-15 years germ cell tumors of the testis (TGCT) are rare and information for a risk adapted therapy limited. AIMS OF THE STUDY The protocol MAHO 98 for patients (pts) with TGCTs is stratified according to age, stage and histology. Pts ≥ 10 years received after tumororchiectomy 2 courses (crs) PVB and restaging. Residual tumor was resected and therapy continued in regard to inital stage and response. Chemotherapy PVB cisplatin (20 mg/m²/day 1-5), vinblastine (3 mg/m²/day 1+2), and bleomycin (15 U/m²/day 1-3). For consolidation 1 crs PVB has been given to stage II patients with CR. In case of PR, 2 crs PEB (vinblastine substituted by etoposide 100 mg/m²/day 1-3) or relapse 3 crs PEI (bleomycin substituted by ifosfamide 1 500 mg/m²/day 1-5) were given.RESULTS:
Between Jan 1998 and Dec 2005, 34 pts (≥ 10 year) were registered, 31 fulfilled the inclusion criteria. Median age 15;6 years; months (range 13;5-20;2 ). Lugano staging IA n=14, IB n=2, IC n=3, IIA n=4, IIB n=6, IIC n=1, IIIC n=1. The stage IIIC pt received preoperative chemotherapy, all other pts had tumororchiectomy first. Residual tumor after 2 crs PVB was detected in 4 pts and was resected. Late relapses occurred in 2 pts and were cured by additional therapy. All patients are surviving.CONCLUSION:
Young patients with TGCT stage I and II have an excellent prognosis and further reduction of therapy has to be considered.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Testicular Neoplasms
/
Orchiectomy
/
Antineoplastic Combined Chemotherapy Protocols
/
Neoplasms, Germ Cell and Embryonal
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
Language:
En
Journal:
Klin Padiatr
Year:
2014
Document type:
Article