EZH2 is a negative prognostic factor and exhibits pro-oncogenic activity in glioblastoma.
Cancer Lett
; 356(2 Pt B): 929-36, 2015 Jan 28.
Article
in En
| MEDLINE
| ID: mdl-25444902
ABSTRACT
The identification of single or less genes based on mRNA expression as clinical diagnostic markers for glioblastoma (GBM) remains a challenge. Recent data have shown the potential oncogenic role and prognostic significance of EZH2 in several human cancers. However, the clinical signature and further mechanisms of EZH2 function in gliomagenesis are still poorly understood. In this study, we found that increased EZH2 expression was associated with tumor grade. High expression of EZH2 in GBM was determined to be a strong and independent predictor of short overall survival. Further, we screened EZH2 targets and associated genes in GBM. Repression of EZH2 induced cell cycle arrest and inhibited tumor growth in vivo. This event represents a positive feedback loop with ß-catenin/TCF4 and STAT3 signaling. Taken together, EZH2 could be an independent prognostic factor and potential therapeutic target for GBM.
Key words
Full text:
1
Collection:
01-internacional
Health context:
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Biomarkers, Tumor
/
Gene Expression Regulation, Neoplastic
/
Glioblastoma
/
Polycomb Repressive Complex 2
/
Neovascularization, Pathologic
Type of study:
Prognostic_studies
Language:
En
Journal:
Cancer Lett
Year:
2015
Document type:
Article