Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa.
Gut Microbes
; 5(6): 761-5, 2014.
Article
in En
| MEDLINE
| ID: mdl-25483327
ABSTRACT
The intestinal mucosa squares the circle by allowing efficient nutrient absorption while generating a firm barrier toward the enteric microbiota, enteropathogenic microorganisms and high luminal concentrations of potent immunostimulatory molecules. The mucus layer together with local antimicrobial and anti-inflammatory peptides significantly contribute to this ability. Here we summarize the recent progress made to better understand the critical importance of this dynamic, complex and highly structured anti-inflammatory and antimicrobial barrier.
Key words
CRS, Cryptdin-related sequence; HD, Human defensin; IAP, Intestinal alkaline phosphatase; LBP, Lipopolysaccharide binding protein; RegIIIγ, Regenerating islet-derived protein 3 γ; SIgA, Secretory immunoglobulin A.; antimicrobial peptides; host-microbial homeostasis; intestine; microbiota; mucosal host defense; mucus layer; paneth cells
Full text:
1
Collection:
01-internacional
Health context:
3_ND
Database:
MEDLINE
Main subject:
Antimicrobial Cationic Peptides
/
Microbiota
/
Intestinal Mucosa
Limits:
Animals
/
Humans
Language:
En
Journal:
Gut Microbes
Year:
2014
Document type:
Article