RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.

Wu, Bo-Kuan; Mei, Szu-Chieh; Brenner, Charles

Wu, Bo-Kuan; Mei, Szu-Chieh; Brenner, Charles.

Affiliation

Wu BK; a Department of Biochemistry; Carver College of Medicine ; University of Iowa ; Iowa City , IA USA.

Cell Cycle ; 13(20): 3222-31, 2014.

Article in En | MEDLINE | ID: mdl-25485502

Subject(s)

DNA (Cytosine-5-)-Methyltransferases/metabolism; Cell Line; Cell Proliferation/physiology; Chromatin Immunoprecipitation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA Methylation/genetics; DNA Methylation/physiology; Humans; Immunoblotting

Key words

COSMIC, catalog of somatic mutation in cancer; DNA methylation; DNMT1; DNMT1, DNA methyltransferase 1; HELP, HpaII tiny fragment enrichment by ligation-mediated PCR; KEGG, Kyoto Encyclopedia of Genes and Genomes; RFTS domain; RFTS, replication foci targeting sequence; TSGs, tumor suppressor genes; chromatin; tumorigenicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA (Cytosine-5-)-Methyltransferases Limits: Humans Language: En Journal: Cell Cycle Year: 2014 Document type: Article

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